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Bupleurum & Dragon Bone / Chai Hu Jia Long Gu Mu Li Tang

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Product Code: CHF-10060

Chinese Classical Formulas (Liquid extracts)


Pubmed Research links on Chai Hu Jia Long Gu Mu Li Tang



Research Report Summary

Herbal Formula Chai Hu Jia Long Gu Mu Li Tang,  Ameliorates Depression through Modulating Hypothalamo-Pituitary-Adrenal (HPA) Axis
A classical Chinese herbal formula, Chai Hu Jia Long Gu Mu Li Tang or Saiko-ka-ryukotsu-borei-to in (kanpo) Japanese herbal medicine, has been used to treat depression, anxiety and insomnia. About one half of depression is caused by attenuation of the dexamethasone-mediated negative feedback on cortisol secretion, which results in disruption of hypothalamo-pituitary-adrenal (HPA) axis.
The researchers at Japan's National Institute for Longevity Sciences examined the effects of Chai Hu Jia Long Gu Mu Li Tang on the chronic stress-induced changes in glucocorticoid receptor (GR) in the PFC and hippocampus. Chronic stress was induced in rats by water immersion and restraint (2 h/day) for 4 weeks.  Chai Hu Jia Long Gu Mu Li Tang significantly prevented decreased cytosolic GRs in the PFC and increased nuclear GRs in the hippocampus in the chronically stressed rats. Moreover, Chai Hu Jia Long Gu Mu Li Tang significantly prevented the abolishment of feedback ability in both regions of brain. These results suggest that the beneficial effects of Chai Hu Jia Long Gu Mu Li Tang on the glucocorticoid receptor level are involved in its ameliorating actions on the HPA disruption and depression.

Additional Information
Ingredients: Filtered water, ethyl alcohol (20%) and a blend of the following dry herbs decocted at a 8:1 ratio (lbs herb to gal. menstruum):
Bupluerum root / Chai Hu 16%
Scutellaria root / Huang Qin 7.9%
Dragon bone mineral / Long Gu 9.5%
Oyster shell mineral / Mu Li 9.5%
Cinnamon twig / Gui Zhi 9.5%
Poria fungus / Fu Ling 7.9%
Pinellia tuber / Ban Xia 12.7%
Fresh Ginger root / Sheng Jiang 7.9%
Ginseng root / Hong Ren Shen 7.9%
Jujube fruit / Hong Zao 7.9%
Rhubarb rhizome / Da Huang 3.2%
* Percent proportion of starting herb.
** 20 drops ˜ 1/4 tspn. (1.25 ml) & contains extractives from 1250 mg of plant material.
Dosage / Directions: Maintenance doseage: Take 30 to 60 drops in water or juice, 2 to 3 times daily.
Augmented Doseage: Take 1 full tsp. 2 to 3 times daily in warm water or juice or as directed by your healthcare provider.

To evaporate alcohol place in hot water.

*These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.