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Momordica fruit (Monk Fruit) / Luo Han Guo

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Product Code: CLS-11900

Chinese Single Herbs (Fluid Extracts)


*These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.


Contraindications and Cautions

  • None Noted.

Herb-Drug Interactions

  • None Noted.

Toxicity and Overdose

  • None Noted.

Reference Source:



In Depth Scholastic Article on Luo Han Guo:




Pubmed Research Article Abstracts:


Phytother Res. 2006 Jul;20(7):552-60.

A natural sweetener, Momordica grosvenori, attenuates the imbalance of cellular immune functions in alloxan-induced diabetic mice.

Song F, Chen W, Jia W, Yao P, Nussler AK, Sun X, Liu L.

Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, P.R. China.


Momordica grosvenori (MG), a traditional medicinal herb in China used as a substitute sugar for obese and diabetic patients, exhibited an enhancement of immunity. Heme oxygenase-1 (HO-1) is among the acute phase proteins that play an important role in the inflammatory process and have antiinflammatory activities with their antioxidant properties. The hypothesis that MG could modulate an imbalance of the cellular immune system and prevent the progression of diabetes mellitus, via induction of HO-1 protein expression was investigated. Diabetes was induced in male Balb/c mice by intraperitoneal injection of alloxan (200 mg/kg). The mice were randomly assigned to non-diabetic and diabetic groups, and further subdivided according to their treatments: control (distilled water), low dose MG (150 mg/kg) and high dose MG (300 mg/kg), which were administered by gavage in 24 h cycles over a 30 day period. MG administration effectively regulated the immune imbalance in diabetic mice, principally by upregulating the CD4(+) T lymphocyte subsets, and remodeling the intracellular cytokine profiles (reducing the expression of pro-inflammatory Th1 cytokines towards a beneficial Th2 pattern), ascribed to its induction and upregulation of HO-1. In conclusion, MG exhibited antidiabetic effects and may be used as a new natural drug for the treatment of diabetes.

PMID: 16619338 [PubMed - indexed for MEDLINE]



Zhonghua Kou Qiang Yi Xue Za Zhi. 1998 May;33(3):183-5.

[Anti-cariogenicity of maceration extract of Momordica grosvenori: laboratory study]

[Article in Chinese]

Mu J.

Zhuhai Institute of Prevent and Treatment of Oral Diseases, Zhuhai 519000.


OBJECTIVE: To study the anti-cariogenicity of Momordica grosvenori a kind of natural sweet fruit.

METHODS: The turbiding method in laboratory was used to test the influence of the maceration extract of Momordica grosvenori on the growth of Streptococcus mutans (S. mutans), glass rod adhering, and acid production. Sucrose, glocose, fructose, beet sugar were designed to compare with Momordica grosvenori.

RESULTS: The growth and fermentation of S. mutans in Momordica grosvenori were significantly lower than these in the other groups includintg beet sugar group (P < 0.01). S. mutans adhering glass rod in Momordica grosvenori was the lowest.

CONCLUSION: Momordica grosvenori possesses many advantages: high sweetness and low adherence, and its anti-cariogenicity is better than beet sugar.

PMID: 11774428 [PubMed - indexed for MEDLINE]



Cancer Lett. 2003 Jul 30;198(1):37-42.

Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori.

Takasaki M, Konoshima T, Murata Y, Sugiura M, Nishino H, Tokuda H, Matsumoto K, Kasai R, Yamasaki K.

Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan.


To search for cancer chemopreventive agents from natural resources, many phytochemicals and food additives have been screened. Consequently, two natural sweeteners, mogroside V and 11-oxo-mogroside V isolated from the fruits of Momordica grosvenori, exhibited strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). These sweet glycosides, having cucurbitane triterpenoid aglycon, exhibited the significant inhibitory effects on the two-stage carcinogenesis test of mouse skin tumors induced by peroxynitrite (ONOO-) as an initiator and TPA as a promoter. Further, 11-oxo-mogroside V also exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumor induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.

PMID: 12893428 [PubMed - indexed for MEDLINE]




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