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Scrophularia / Xuan Shen

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Product Code: CLS-12540

Chinese Single Herbs (Fluid Extracts)


*These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.

Chinese Herbal Actions:

  • Clears Heat, Cools the Blood, and Nourishes the Yin
    Use when heat has entered the Blood level causing fever, bleeding, dry mouth, and a red-purple tongue color. Also for Yin Deficiency heat, especially following a fever with dryness, constipation, irritability, and dry cough.
  • Relieves Fire Toxicity and Inflammation
    For red or swollen eyes and severe sore throat.
  • Resolves Nodules and Lumps
    For neck lumps, swollen tonsils, scrofula, and swollen throat from phlegm fire.

Reference Source:



Scholastic Research Article:





PubMed Research Article Abstracts


Acta Pharmacol Sin. 2000 Dec;21(12):1125-8.

Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl.

Li YM, Han ZH, Jiang SH, Jiang Y, Yao SD, Zhu DY.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.


AIM: To investigate the antioxidative activity of the constituents of the roots of Scrophularia ningpoensis (Chinese name: Xuanshen).

METHODS: The main compounds from the roots of Scrophularia ningpoensis were isolated and identified by chromatography and FABMS, NMR etc. Using the techniques of pulse radiolysis, the electron transfers from iridoid glycosides (IG) or phenylpropanoid glycosides (PG) to oxidized OH radical adducts of 2'-deoxyadenosine-5'-monophosphate acid (dAMP) or 2'-deoxyguanosine-5'-monophosphate acid (dGMP) were observed.

RESULTS: Two IG: harpagoside and harpagide, two PG: angoroside C and acteoside were obtained as the main hydrophilic constituents of the plant. At 0.1 mmol/L concentration, angoroside C and acteoside were able to repair the oxidized OH adducts dAMP and dGMP significantly. However, harpagoside and harpagide had no such effect. The electron transfer rate constants of angoroside C with dAMP and dGMP were 4.2 x 10(8) and 10.3 x 10(8) L.mol-1.s-1; the electron transfer rate constants of acteoside with dAMP and dGMP were 5.3 x 10(8) and 20.2 x 10(8) L.mol-1.s-1.

CONCLUSION: PG from Scrophularia ningpoensis have a potent antioxidative activity for reducing of the oxidized OH adducts of dAMP and dGMP.

PMID: 11603287 [PubMed - indexed for MEDLINE]



Biol Pharm Bull. 2000 May;23(5):599-601.

Inhibitory effects of methanol extracts of herbal medicines on substance P-induced itch-scratch response.

Tohda C, Kakihara Y, Komatsu K, Kuraishi Y.

Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan.


In a search for new anti-pruritic drugs we screened methanol extracts of 33 herbal medicines which have been used for cutaneous diseases for their antipruritic activity using substance P (SP) as a pruritogen in mice. When administered perorally 30 min before SP injection, methanol extracts of 6 of these herbal medicines, the root of Scrophularia ningpoensis Hemsl., the root of Patrinia villosa (Thunb.) Juss, the fruit of Forsythia suspenna Vahl, the rhizome of Cimicifuga dahurica (Turcz.) Maxim., the aerial part of Schizonepeta tenuifolia Briq. and the fruit of Cnidium monnieri (L.) Cuss, inhibited SP-induced itch-scratch response at a dose of 200 mg/kg with-out affecting locomotor activity. Dose dependence of these 6 extracts (50-500 mg/kg) was investigated and all of them inhibited SP-induced itch-scratch response, with extracts from Scrophularia ningpoensis, Schizonepeta tenuifolia and Cnidium monnieri showing particularly significant inhibition. The results suggest that these 6 methanol extracts have inhibitory activity against SP-induced itching.

PMID: 10823672 [PubMed - indexed for MEDLINE]

Additional Information
Cautions / Contraindications: * Contraindicated in patients with diarrhea, or dampness in the spleen or stomach. This herb has been noted to antagonize Rhizoma Zingiberis Officinalis (gan jiang), Radix Astragali Membranacei (huang qi), Fructus Zizyphi Jujubae (da zao), Frucutus Corni Officinalis (shan zhu yu), and is incompatible with Rhizoma et Radix Veratri (li lu).

Herb-Drug Interactions:

* May interfere with Anti-Diabetic drugs.

Toxicity and Overdose:

* This section is being researched, and is not completed.


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